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KMID : 0380620150470030388
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Korean Journal of Food Science and Technology
2015 Volume.47 No. 3 p.388 ~ p.393
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Radioprotective Effect of Post-treatment with Rutin on γ-Irradiation-induced Cellular Damage in Mice
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Kang Jung-Ae
Yoon Seon-Hye
Rho Jong-Kook
Choi Dae-Seong
Jang Beom-Su
Park Sang-Hyun
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Abstract
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This study aimed to investigate the therapeutic effect of rutin against whole-body γ-irradiation in BALB/c mice. BALB/c mice were randomly divided into four groups and exposed to 6 Gy γ-irradiation. One hour later, mice were orally administered rutin (50 and 100 mg/kg) for seven consecutive days. γ-Irradiation (6 Gy) resulted in cellular damage as manifested by elevated levels of plasma hepatic marker enzymes and lipid peroxidation in liver tissue, accompanied with decreased spleen and thymus indices, and white blood cell count. In addition, γ-irradiation significantly decreased the levels of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and catalase. Rutin treatment significantly protected against γ-irradiation-induced cellular damage, which was evident by the improvement in the status of most of the investigated parameters. Therefore, rutin has beneficial effects against radiation-induced damage.
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KEYWORD
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rutin, γ-irradiation, cellular damage
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